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6.5.3 Amyotrophic lateral sclerosis (ALS) ALS is a CNS illness that leads to the loss of nerve cells that control movement

Evidence standard: Every major claim is graded in the evidence ledger below

The evolving role of the NAD+/nicotinamide metabolome in skin homeostasis, cellular bioenergetics, and aging

Among them, the ECM-receptor interaction and focal adhesion pathways play essential roles in cell proliferation, cell differentiation and cell survival, and are pivotal in tissue and organ morphogenesis (61)